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Platelets in Suspension Require Preactivation to Adhere to Immobilized Fibrinogen
Author(s) -
BONNEFOY ARNAUD,
LIU QINGDE,
JEROME W. GRAY,
LEGRAND CHANTAL,
FROJMOVIC MONY M.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03531.x
Subject(s) - platelet , fibrinogen , chemistry , suspension (topology) , adenosine diphosphate , whole blood , perfusion , biophysics , platelet adhesiveness , chromatography , biochemistry , platelet aggregation , immunology , medicine , biology , mathematics , homotopy , pure mathematics
A bstract : Previous studies using whole blood perfusion through flow chambers have suggested that unactivated platelets can adhere to surface immobilized fibrinogen (Fg). However, the red blood cells needed for surface delivery of the platelets may activate platelets by released adenosine diphosphate (ADP). Our studies of coaggregation of unactivated or ADP‐activated platelets with Fg‐coated latex beads in flowing suspensions show that only preactivated platelets can adhere to Fg‐coated surfaces.