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Cellular Mechanisms of Calcium and Vitamin D in the Inhibition of Colorectal Carcinogenesis
Author(s) -
LAMPRECHT SERGIO A.,
LIPKIN MARTIN
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb02729.x
Subject(s) - calcium , carcinogenesis , vitamin d and neurology , vitamin , colorectal cancer , chemistry , calcium signaling , cancer research , medicine , pharmacology , endocrinology , biochemistry , cancer
Convincing evidence is available showing that dietary calcium and vitamin D impede the development of colonic carcinogenesis. The major cellular modes of action of calcium and vitamin D which can contribute to the inhibition of colonic neoplasia are reviewed in this article. These consist of complex series of signaling events induced by the chemopreventive agents acting at various tiers of colonic cell organization.