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Bone Marrow as a Source of Endothelial Cells for Natural and Iatrogenic Vascular Repair
Author(s) -
ISNER JEFFREY M.,
KALKA CHRISTOPH,
KAWAMOTO ATSUHIKO,
ASAHARA TAKAYUKI
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb02075.x
Subject(s) - vasculogenesis , angiogenesis , neovascularization , progenitor cell , blood vessel , bone marrow , biology , microbiology and biotechnology , medicine , immunology , stem cell , cancer research , endocrinology
A bstract : Postnatal neovascularization has previously been considered synonymous with angiogenesis, but the finding that circulating endothelial progenitor cells (EPCs) may home to sites of neovascularization and there differentiate into endothelial cells (ECs) is consistent with “vasculogenesis,” through which the primordial vascular network is established in the embryo. Our findings suggest that growth and development of new blood vessels in the adult are not restricted to angiogenesis but encompass vasculogenesis as well, although the proportional contributions remain to be clarified. Likewise, augmented or retarded neovascularization probably involves enhancement or impariment of the vasculogenesis process.