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The Value of Transgenic Models for the Study of Neurodegenerative Diseases
Author(s) -
PRICE DONALD L.,
WONG PHILIP C.,
MARKOWSKA ALICJA L.,
LEE MICHAEL K.,
THINAKAREN GOPAL,
CLEVELAND DONALD W.,
SISODIA SANGRAM S.,
BORCHELT DAVID R.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06920.x
Subject(s) - transgene , genetically modified mouse , mutant , biology , sod1 , gene , microbiology and biotechnology , neuroscience , computational biology , genetics
A bstract : Transgenic animal models are useful in studying the features of APP‐ and PS1‐linked FAD and SOD1‐linked FALS. These models help to investigate the nature of the cellular/biochemical/molecular alterations in neural tissue; the character and evolution of neuronal and/or glial abnormalities; the ways mutant proteins cause damage to neurons; and the biochemical pathways associated with cell death. New technologies will help to define changes in a variety of genes/gene products and the events and conformational changes in mutant proteins that are implicated in pathogenic cascades. It is hoped such study will result in novel treatments for testing in transgenic models that can then be translated into new treatments for human neurodegenerative diseases.