Premium
Role of Presenilin‐1 in Murine Neural Development
Author(s) -
YANG XUDONG,
HANDLER MELISSA,
SHEN JIE
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06918.x
Subject(s) - neurogenesis , notch signaling pathway , presenilin , progenitor cell , microbiology and biotechnology , neural stem cell , neural development , effector , notch 1 , progenitor , biology , hes1 , cell growth , signal transduction , neuroscience , medicine , gene , stem cell , genetics , disease , alzheimer's disease
A bstract : Our previous studies showed that presenilin‐1 (PS1) is required for murine neural and skeletal development. Here we report that the reduction in the neural progenitor cells observed in the PS1 −/− mouse brain is due to premature differentiation of progenitor cells, rather than to increased apoptotic cell death or decreased cell proliferation. In the ventricular zone of PS1 −/− mice, expression of the Notch1 downstream effector gene Hes5 is reduced, and expression of the Notch1 ligand Dll1 is elevated, indicating reduced Notch signaling. These results provide direct evidence that PS1 is involved in the regulation of neurogenesis and Notch signaling during development.