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Animal Models to Assess the Effects of Air Pollutants on Allergic Lung Disease
Author(s) -
SELGRADE MARYJANE K.,
LAMBERT AMY L.,
WARD MARSHA D. W.,
GILMOUR M. IAN
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06883.x
Subject(s) - asthma , human health , human disease , disease , allergy , animal model , air pollutants , pollutant , medicine , lung disease , immunology , respiratory allergy , environmental health , intensive care medicine , risk analysis (engineering) , lung , biology , air pollution , pathology , ecology , allergen
A bstract : Animal models provide toxicologists with useful tools for assessing risks associated with respiratory allergy. Both the mouse and BN rat models described exhibit many of the features of human allergic asthma. It is clear that environmental contaminants can exacerbate the expression of these features. Work is under way to explore underlying mechanisms and to develop methods for applying these data to human health risk assessment.