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Aging and Resistance to Trichinella spiralis Infection following Xenobiotic Exposure
Author(s) -
LUEBKE ROBERT W.,
COPELAND CAREY B.,
ANDREWS DEBORA L.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06882.x
Subject(s) - xenobiotic , immunosenescence , immune system , immunology , trichinella spiralis , biology , host resistance , population , drug resistance , microbiology and biotechnology , medicine , antigen , environmental health , biochemistry , enzyme
A bstract : Aging is accompanied by well‐documented physiological changes, including alterations in the immune system that can lead to reduced resistance to a variety of infectious agents. We tested the hypothesis that immunosenescence exacerbates the immunosuppressive effect of xenobiotics. If proven true, a given dose of an immunosuppressive xenobiotic would cause greater suppression of host resistance in an aged population.