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The Role of Tumor Necrosis Factor α in Chemical‐Induced Hepatotoxicity
Author(s) -
LUSTER MICHAEL I.,
SIMEONOVA PETIA P.,
GALLUCCI RANDLE M.,
BRUCCOLERI ALEX,
BLAZKA MARK E.,
YUCESOY BERRAN,
MATHESON JOANNA M.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06881.x
Subject(s) - tumor necrosis factor alpha , inflammation , tumor necrosis factor α , medicine , bioinformatics , biology , immunology
A bstract : Only recently have toxicologists come to understand the role of inflammation, and TNFα specifically, in classical toxicological processes. This relationship appears fairly complex, as inflammation and proliferation may well be only one facet of a time‐ and dose‐dependent continuum of toxicological and repair processes. Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFα for potential therapeutic use. Their effectiveness in controlling environmental or occupational diseases has yet to be established.