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Use of Oligonucleotide Arrays to Analyze Drug Toxicity
Author(s) -
KAMINSKI NAFTALI,
ALLARD JOHN,
HELLER RENU A.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06861.x
Subject(s) - toxicity , drug , computational biology , drug toxicity , pharmacology , oligonucleotide , drug development , drug discovery , biology , gene , bioinformatics , chemistry , genetics , organic chemistry
A bstract : The advent of oligonucleotide arrays allows the simultaneous analysis of the expression of thousands of genes. This powerful technology, highly dependent on advanced analysis tools, can transform the level of information currently available on the mechanisms underlying drug‐related toxicity. It is now possible to analyze the global transcriptional response to a drug and determine the global pathways associated with the effects of this agent. This analysis can be performed on samples from patients that developed a toxic effect, on cells exposed to the toxic agent, and in animal models of toxicity. Especially useful is the comparison of transcriptional responses in animals susceptible to drug‐induced disease with those of genetically modified animals that are resistant to this effect. This analytic strategy allows the delineation of specific mechanisms relevant and specific to drug‐induced toxicity and thus might lead to novel therapeutic interventions in these toxic reactions.