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The Parahippocampal Cortices and Kindling
Author(s) -
McINTYRE DAN C.,
KELLY MARY ELLEN
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06736.x
Subject(s) - perirhinal cortex , kindling , piriform cortex , neuroscience , entorhinal cortex , temporal lobe , parahippocampal gyrus , hippocampus , limbic system , amygdala , epilepsy , psychology , central nervous system
A bstract : The piriform and perirhinal cortices are parahippocampal structures with strong connections to limbic structures, including the amygdala and hippocampus, as well as other parahippocampal structures such as the entorhinal cortex. In this paper, we present results, based on anatomical, physiological, and kindling studies, that suggest that the perirhinal and piriform cortices might be very important in the secondary generalization of limbic seizures, particularly those with convulsive expression. These kindling data further suggest that the progressive lowering of afterdischarge thresholds in the parahippocampal structures, due to insult and/or genetic predisposition, might provide the neural basis for the clinical presentation of temporal lobe epilepsy.