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Different Pathways of Colorectal Carcinogenesis and Their Clinical Pictures
Author(s) -
TOMLINSON IAN
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06697.x
Subject(s) - genome instability , carcinogenesis , biology , colorectal cancer , selection (genetic algorithm) , genetics , phenotype , cancer research , microsatellite instability , cancer , computational biology , gene , dna damage , dna , computer science , artificial intelligence , allele , microsatellite
A bstract : An entertaining debate in cancer genetics concerns the relative importance of selection for a growth advantage and genomic instability in tumorigenesis. Below, I present evidence that shows that selection is more important, particularly in the early stages of tumorigenesis, but that genomic instability is also an indisputable feature of many cancers. One attractive possibility is that some mutations may have pleiotropic effects both on cell replication or apoptosis and on genomic instability.