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GABA Modulation of Cocaine Self‐Administration
Author(s) -
ROBERTS DAVID C.S.,
BREBNER KAREN
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06680.x
Subject(s) - baclofen , reinforcement , self administration , agonist , pharmacology , gabab receptor , neuroscience , anesthesia , medicine , psychology , receptor , social psychology
A bstract : Recent experiments suggest that GABA compounds produce a clinically relevant modulation of cocaine reinforcement. This review summarizes the results of a number of studies that examined the effect of the GABA B agonist baclofen on cocaine self‐administration using a variety of schedules of reinforcement. The results demonstrate that baclofen causes a dramatic reduction in cocaine self‐administration which does not appear to be accounted for by a general disruption of behavior. However, the effect is dependent on the unit injection dose of cocaine and on the response requirements of the schedule. These results predict that in a clinical setting any potential therapeutic effect of baclofen will interact with the cost and availability of cocaine.