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Fibroblast Responses to Exogenous and Autocrine Growth Factors Relevant to Tissue Repair: The Effect of Aging
Author(s) -
KLETSAS DIMITRIS,
PRATSINIS HARRIS,
ZERVOLEA IRENE,
HANDRIS PANAGIOTIS,
SEVASLIDOU ELENI,
OTTAVIANI ENZO,
STATHAKOS DIMITRI
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06644.x
Subject(s) - autocrine signalling , fibroblast , extracellular matrix , context (archaeology) , microbiology and biotechnology , wound healing , extracellular , chemotaxis , in vitro , growth factor , matrix metalloproteinase , biology , chemistry , immunology , biochemistry , receptor , paleontology
A bstract : The aging process is often associated with impaired wound healing, but the cellular and molecular mechanisms implicated are not completely understood. Accordingly, we have investigated the response of human fibroblasts from donors of various ages to platelet‐derived and autocrine growth factors, in terms of mitogenicity as well as extracellular matrix synthesis and degradation. Our data indicate that fibroblast responses persist during aging, suggesting the involvement of systemic factors in the regulation of the healing process. In this context, we have found that neutral endopeptidase‐24.11, a metalloproteinase controlling the action of neuroendocrine peptides and also of immunocyte chemotaxis, is overexpressed during aging. Finally, the connection between these data and those from in vitro aging studies is discussed.