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Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabditis elegans
Author(s) -
MURAKAMI SHIN,
TEDESCO PATRICIA M.,
CYPSER JAMES R.,
JOHNSON THOMAS E.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06634.x
Subject(s) - longevity , caenorhabditis elegans , biology , transcription factor , microbiology and biotechnology , life span , genetics , kinase , receptor tyrosine kinase , insulin receptor , evolutionary biology , gene , insulin , insulin resistance , endocrinology
A bstract : Aging and a limited life span are fundamental biological realities. Recent studies have demonstrated that longevity can be manipulated and have revealed molecular mechanisms underlying longevity control in the soil nematode Caenorhabditis elegans . Signals from both neurons and the gonad appear to negatively regulate longevity. One tissue‐specific signal involves an insulin‐like phosphatidylinositol 3‐OH kinase pathway, dependent upon the DAF‐16 forkhead transcription factor. These signals regulate mechanisms determining longevity that include the OLD‐1 (formerly referred to as TKR‐1) receptor tyrosine kinase. Interestingly, increased resistance to environmental stress shows a strong correlation with life extension.