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Contrast‐enhanced MRI of White Matter Lesions in Patients with Blood‐Brain Barrier Dysfunction
Author(s) -
WAHLUND LARSOLOF,
BRONGE LENA
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06402.x
Subject(s) - hyperintensity , blood–brain barrier , magnetic resonance imaging , white matter , gadolinium , dementia , albumin , contrast (vision) , pathology , medicine , disease , chemistry , central nervous system , radiology , organic chemistry , artificial intelligence , computer science
A bstract : White matter lesions (WMLs) and blood‐brain barrier (BBB) dysfunction are common in dementia. Both conditions may be a consequence of small‐vessel disease, in which case the BBB damage could be suspected to be located to the WMLs. Magnetic resonance imaging (MRI) can be used to show WMLs as well as to detect BBB damage when using an intravenous contrast agent, gadolinium. We examined 10 demented patients with WMLs, including 5 cases with BBB (elevated CSF/serum albumin ratios). Results showed no significant changes in MR signal in the WMLs after contrast administration. We conclude that WMLs are not related to BBB damage to such a degree that is detectable with this method and that the elevated CSF albumin might have another origin.