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Linear Relation between Cerebral Phosphocreatine Concentration and Memory Capacities during Permanent Brain Vessel Occlusions in Rats
Author(s) -
PLASCHKE KONSTANZE,
YUN SEONGWOOK,
MARTIN EIKE,
HOYER SIEGFRIED,
BARDENHEUER HUBERT J.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06380.x
Subject(s) - phosphocreatine , occlusion , medicine , cardiology , cerebral cortex , neuroscience , chemistry , psychology , energy metabolism
A bstract : The present study investigates the interrelation between cerebral energy state and memory capacities in a rat model of stepwise cerebral vessel occlusions. After acute and subchronic permanent vessel occlusions, cortical energy metabolites (ATP, phosphocreatine, ADP, AMP) were detected by high‐pressure liquid chromatography (HPLC) analysis, and the effects on learning, memory, and cognitive behavior were evaluated using a holeboard test. The results of the study demonstrated a drastic decrease in energy‐rich phosphates by 33% for phosphocreatine and by 44% for ATP after acute vessel occlusions. In addition, rat working and reference memories were strikingly decreased to about 5% of controls. In contrast, two weeks after four‐vessel occlusion, the energy state was almost completely restored to control levels. However, a significant decrease in memory capacities was observed in subchronic state. In summary, this study has demonstrated a close linear relationship ( p < 0.001 ) between an impaired cerebral energy state and brain memory dysfunction after acute and permanent cerebral four‐vessel occlusion. Thus, this animal model of stepwise reduction of the cerebral blood supply may reflect some clinically relevant processes occurring during cerebrovascular and neurodegenerative diseases.