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The Fat Mouse: A Powerful Genetic Model to Study Hemostatic Gene Expression in Obesity/NIDDM
Author(s) -
LOSKUTOFF DAVID J.,
FUJISAWA KAZUHIKO,
SAMAD FAHUMIYA
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06322.x
Subject(s) - obesity , endocrinology , medicine , adipocyte , biology , tumor necrosis factor alpha , gene expression , gene , adipose tissue , genetics
A bstract : In this chapter, we summarize our studies on plasminogen activator inhibitor 1 (PAI‐1), tissue factor, and transforming growth factor beta (TGF‐β) expression in obesity, using genetically obese mice as a model. These studies emphasize the key role played by the adipocyte, a cell whose numbers, size, and metabolic activity are grossly altered in obesity/NIDDM. They also implicate multiple cytokines, hormones, and growth factors in the abnormal expression of these and perhaps other hemostatic genes by adipocytes in obesity/NIDDM. These studies demonstrate that tumor necrosis factor alpha (TNF‐α) plays a central role in the expression of hemostatic genes in this disorder.