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Autoimmune Antiovarian Antibodies and Their Impact on the Success of an IVF/ET Program
Author(s) -
HOŘEJŠÍ JAN,
MARTÍNEK JINDRICH,
NOVÁKOVÁ DANA,
MADAR JINDRICH,
BRANDEJSKA MILADA
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06248.x
Subject(s) - antibody , immunology , medicine
A bstract : In previous papers, we referred to studies of the influence of anti‐ovarian autoantibodies on menstrual cycle disorders in adolescent girls. We examined autoantibodies against ooplasma, zona pellucida, membrana granu‐losa, theca folliculi interna, and lutein cells. In infertile women in the IVF/ET program, we studied the positivity of antiovarian antibodies and cytokines, namely, TNF‐α and IL‐1β, in follicular fluid correlated with the following sub‐groups, characterized by the outcome of in vitro fertilization, as follows: G, pregnant; F, fertilized; N, nonfertilized; and O, no oocyte gained. The presence of autoantibodies corresponds to the success or failure of the IVF/ET program. Our results support the hypothesis that antiovarian autoantibodies play an important role in both the endocrine and the reproductive function of the human ovary and that it can influence them negatively.