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Molecular Defects Causing Ovarian Dysfunction
Author(s) -
KALANTARIDOU SOPHIA N.,
CHROUSOS GEORGE P.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06214.x
Subject(s) - molecular genetics , pathophysiology , premature ovarian failure , medicine , bioinformatics , biology , gene , endocrinology , genetics
A bstract : The functions of the hypothalamic‐pituitary‐ovarian and ‐adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovarian failure, and heterosexual or isosexual precocious puberty have recently been described. The molecular insights gained into ovarian dysfunction have already led to rational therapies for some of these conditions.