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Mechanisms of Cell Death Governed by the Balance between Nitrosative and Oxidative Stress
Author(s) -
ESPEY MICHAEL GRAHAM,
MIRANDA KATRINA M.,
FEELISCH MARTIN,
FUKUTO JON,
GRISHAM MATHEW B.,
VITEK MICHAEL P.,
WINK DAVID A.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06188.x
Subject(s) - peroxynitrite , reactive nitrogen species , oxidative stress , reactive oxygen species , chemistry , oxidative phosphorylation , superoxide , nitric oxide , oxygen , nitrosylation , biophysics , nitrosation , nitroxyl , biochemistry , photochemistry , biology , enzyme , organic chemistry
A bstract : Many cellular functions in physiology are regulated by the direct interaction of NO with target biomolecules. In many pathophysiologic and toxicologic mechanisms, NO first reacts with oxygen, superoxide or other nitrogen oxides to subsequently elicit indirect effects. The balance between nitrosative stress and oxidative stress within a specific biological compartment can determine whether the presence of NO will be ultimately deleterious or beneficial. Nitrosative stress can be defined primarily through reactions mediated by N 2 O 3 , a reactive nitrogen oxide species generated by high fluxes of NO in an aerobic environment. In contrast, oxidative stress is mediated primarily by superoxide and peroxides. In addition to reactive oxygen species, several reactive nitrogen oxide species such as peroxynitrite, nitroxyl, and nitrogen dioxide can also impose oxidative stress to a cell. We here describe how the mechanisms of cell death are interwoven in the balance between the different chemical intermediates involved in nitrosative and oxidative stress.