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Role of Apoptosis in the Response of Lung Carcinomas to Anti‐Cancer Treatment
Author(s) -
JOSEPH BERTRAND,
LEWENSOHN ROLF,
ZHIVOTOVSKY BORIS
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05613.x
Subject(s) - apoptosis , lung cancer , radiation therapy , chemotherapy , cancer research , cell cycle , cancer , programmed cell death , medicine , cell , cancer cell , biology , immunology , pathology , biochemistry , genetics
A bstract : Resistance of tumor cells to treatment often accounts for the failure of traditional forms of anti‐cancer therapy. It is well known that tumors from the same histological group and stage of development are highly heterogeneous in their sensitivity to therapy. Among the factors that can influence tumor sensitivity are DNA repair capacity, distribution of cells throughout the cell cycle, proliferation potential, etc. In many cases, anti‐cancer therapy eliminates tumor cells via apoptosis, an active form of cell death characterized by cell shrinkage and the removal of cells in a neat, orderly fashion. However, this process is not always efficient. In the present review, the precise role that apoptosis plays in the response of lung carcinomas to chemotherapy and radiation treatment is discussed.