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The Role of the Pro‐Apoptotic Bcl‐2 Family Member Bim in Physiological Cell Death
Author(s) -
BOUILLET PHILIPPE,
HUANG DAVID C.S.,
O'REILLY LORRAINE A.,
PUTHALAKATH HAMSA,
O'CONNOR LIAM,
CORY SUZANNE,
ADAMS JERRY M.,
STRASSER ANDREAS
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05601.x
Subject(s) - multicellular organism , autoimmunity , apoptosis , programmed cell death , microbiology and biotechnology , biology , haematopoiesis , immune system , immunology , cell , cancer research , stem cell , genetics
A bstract : Apoptosis, an evolutionarily conserved process for killing unwanted cells in multicellular organisms, is essential for normal development, tissue homeostasis and as a defense against pathogens. The control of apoptosis is of considerable importance for clinical medicine, as its deregulation can lead to cancer, autoimmunity or degenerative diseases. We have disrupted the Bim gene in the mouse and demonstrated that it plays a major and non‐redundant role in embryogenesis, in the control of hematopoietic cell death, and as a barrier against autoimmunity.