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Oxidative Metabolism
Author(s) -
BEAL M. FLINT
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05575.x
Subject(s) - oxidative metabolism , oxidative phosphorylation , oxidative damage , metabolism , cytochrome c oxidase , disease , biochemistry , oxidative stress , chemistry , enzyme , medicine
A bstract : There is a large body of evidence showing both metabolic defects and oxidative damage in Alzheimer's disease. Studies of cybrid cell lines show reduced cytochrome oxidase. There is also substantial evidence for a defect in a‐ketoglutarate dehydrogenase. It is therefore possible that therapeutic strategies to improve brain metabolism or ameliorate oxidative damage might be useful in treating Alzheimer's disease.