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Oxidative Stress Leading to Loss of Critical Proteases in Alzheimer's Disease: An Alternative View of the Etiology of AD
Author(s) -
CARNEY JOHN M.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05574.x
Subject(s) - proteases , oxidative stress , disease , etiology , oxidative damage , neurodegeneration , alzheimer's disease , medicine , extant taxon , oxidative phosphorylation , neuroscience , biology , pathology , biochemistry , enzyme , evolutionary biology
A bstract : An alternative view of the etiology of Alzheimer's disease is suggested which focuses on the relationship between oxidative stress and the decrease in proteases seen in aging. Proteases act to govern the acceleration of the pathology of aging and, as damage from oxidative stress increases, the loss of proteases in at‐risk persons leads to symptoms of AD. Controlling the damage to proteases or controlling the generator(s) of oxidative stress may help to control the onset or progression of Alzheimer's disease.