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Synaptic Structure and Function in Transgenic APP Mice
Author(s) -
ASHE KAREN HSIAO
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05558.x
Subject(s) - genetically modified mouse , transgene , neuroscience , hippocampal formation , dementia , amyloid precursor protein , alzheimer's disease , amyloid (mycology) , electrophysiology , disease , biology , medicine , pathology , biochemistry , gene
A bstract : Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.