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The Pathogenesis of Alzheimer's Disease: Is Amyloid β‐Protein the Beginning or the End?
Author(s) -
YANKNER BRUCE A.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05555.x
Subject(s) - pathogenesis , disease , alzheimer's disease , causality (physics) , amyloid (mycology) , biochemistry of alzheimer's disease , amyloid beta , neuroscience , medicine , amyloid β , clinical trial , amyloid precursor protein , immunology , psychology , pathology , physics , quantum mechanics
A bstract : A central issue in Alzheimer's disease research is whether amyloid β‐protein (Aβ) is a cause or effect of the pathogenic process. Several independent lines of evidence argue for causality, although human clinical trials may be required to finally settle the issue.