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Therapeutic Applications of Antiflammin Peptides in Experimental Ocular Inflammation
Author(s) -
CHAN CHICHAO,
TUAILLON NADINE,
LI QIAN,
SHEN FEN
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05525.x
Subject(s) - inflammation , proinflammatory cytokine , phospholipase a2 , in vivo , annexin a1 , nitric oxide synthase , immunology , uveitis , pharmacology , cytokine , allergic inflammation , nitric oxide , in vitro , chemistry , carrageenan , medicine , biology , enzyme , annexin , biochemistry , endocrinology , microbiology and biotechnology
A bstract : Antiflammins are synthetic peptides derived from the region of highest local similarity between uteroglobulin and lipocortin. These peptides have shown anti‐inflammatory activity on carrageenan‐induced rat footpad edema. They are potent inhibitors for phospholipase A 2 activation both in vitro and in vivo . Previously, we have demonstrated the effectiveness of topical antiflammins in suppressing acute ocular inflammation and allergic response in rodent endotoxin‐induced uveitis and murine allergic conjunctivitis. The mechanisms by which antiflammins protect against inflammation and allergy in these ocular models may involve inhibition of phospholipase A 2 and inducible nitric oxide synthase (iNOS) as well as the production of proinflammatory cytokine, interleukin‐6.