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Generation of Cytotoxic T Lymphocytes and Cytostatic Acting Cells in T. annulata ‐Immune Cattle
Author(s) -
AHMED J. S.,
WIEGERS P.,
RITZ H.,
HARTWIG H.,
SCHEIN E.,
SCHNITTGER L.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05342.x
Subject(s) - cytotoxic t cell , ctl* , immune system , biology , cytotoxicity , major histocompatibility complex , immunology , interferon gamma , mhc class i , virology , cd8 , in vitro , biochemistry
A bstract : Cattle immunized against Theileria annulata with schizont containing autologous cell lines are immune to challenge with a homologous parasite strain. Two cell types have been detected in the peripheral blood of the immunized animals: cytotoxic T lymphocytes (CTL) and cytostatic acting cells (CAC). Killing the target cells by CTL is infection associated and is MHC class I restricted. Hence, no cytotoxicity was observed against target cells that were treated with the theilericidal drug buparvaquone or autologous Con A‐blasts. The growth inhibition of CAC is MHC unrestricted, and not mediated by cytokine interferon gamma (IFN‐γ).