Premium
Neutrophil Migration across Intestinal Epithelium
Author(s) -
JAYE DAVID L.,
PARKOS CHARLES A.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05238.x
Subject(s) - intestinal epithelium , epithelium , ulcerative colitis , pathology , immunology , disease , biology , pathophysiology , inflammatory bowel disease , medicine
A bstract : Transmigration of neutrophils across epithelial surfaces is the hall‐mark of inflammatory mucosal diseases of diverse organs. In disorders such as Crohn's disease, ulcerative colitis, pyelonephritis, and bronchitis, for example, neutrophil transmigration correlates with clinical disease activity, is associated morphologically with injury to the epithelium, and is central to disease pathophysiology. The mechanisms by which neutrophils transmigrate across epithelia are, therefore, of considerable significance for numerous pathologic states. In this paper, we discuss current evidence that defines these mechanisms in intestinal epithelium, emphasizing the structural constituents determining adhesive interactions and a subset of the complex regulatory signals between neutrophils and epithelium.