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Directed Coherence of EEG on ICSS Rats with Methamphetamine‐induced Hyperactivity and Stereotyped Behavior
Author(s) -
TAKIGAWA MORIKUNI,
WANG HUDONG,
HAMADA KOICHI,
SHIRATANI TOSHIHIRO,
TAKENOUCHI KAORU
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05206.x
Subject(s) - stereotypy , ventral tegmental area , neuroscience , psychology , methamphetamine , prefrontal cortex , amphetamine , attention deficit hyperactivity disorder , behavioral sensitization , dopamine , dopaminergic , cognition , nucleus accumbens , psychiatry
Methamphetamine (MAP) can reinforce intracranial self-stimulation (ICSS) in rats, that is, reward-seeking behavior. However, the ICSS can be inhibited by the stereotyped behavior induced by MAP. This study was designed to observe the mutual information flow between prefrontal cortex (PFC) and ventral tegmental area (VTA) using directed coherence (DC) analysis during the hyperactivity and stereotyped behavior induced by administration of MAP (a derivative of amphetamine). The DC from PFC to VTA increased at 5-7 Hz in the hyperactivity as compared to the stereotypy. In contrast, enhanced information flow from VTA to PFC was observed in the stereotypy as compared to the hyperactivity. We found a reciprocal information flow between PFC and VTA corresponding to the hyperactivity and stereotyped behavior that was induced by administration of MAP.