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Dopamine Uptake Blockers Nullify Methamphetamine‐induced Decrease in Dopamine Uptake and Plasma Membrane Potential in Rat Striatal Synaptosomes
Author(s) -
WESTPHALEN R. I.,
STADLIN A.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05195.x
Subject(s) - dopamine , methamphetamine , chemistry , pharmacology , medicine
Rat striatal synaptosomes showed a reduced capacity to generate a membrane potential after being exposed to methamphetamine (METH) for 1 h. As a consequence, the dopamine (DA) synaptosomes were impeded in their electrogenic‐dependent reuptake of dopamine. The capacity for METH‐exposed nerve terminals to generate a membrane potential may contribute to the ability of METH to destroy dopaminergic neurons. DA uptake inhibitors (DAUIs) were found to counteract the METH‐induced decrease in synaptosomal [ 3 H]DA Vmax by stablizing METH‐induced reductions in PMP. Because DAUIs showed the same effects as a Na+‐channel blocker, DAUIs may prevent METH‐induced destruction of dopaminergic neurons by raising plasma membrane potential.