Premium
Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein‐Gated K + Channel, I KACh
Author(s) -
WICKMAN KEVIN,
KRAPIVINSKY GRIGORY,
COREY SHAWN,
KENNEDY MATT,
NEMEC JAN,
MEDINA IGOR,
CLAPHAM DAVID E.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb11300.x
Subject(s) - potassium channel , chemistry , biophysics , biochemistry , pharmacology , medicine , biology
The muscarinic‐gated atrial potassium channel I KACh has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of I KACh have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac I KACh , the mechanism of activation of I KACh by G proteins, and the relevance of I KACh to cardiac physiology.