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Hereditary Pancreatitis and Pancreatic Carcinoma
Author(s) -
WHITCOMB DAVID C.,
APPLEBAUM SUZANNE,
MARTIN STEPHEN P.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb09524.x
Subject(s) - pancreatitis , hereditary pancreatitis , medicine , pancreatic cancer , trypsinogen , gastroenterology , incidence (geometry) , prospective cohort study , pancreatic disease , risk factor , pancreas , cancer , trypsin , biochemistry , physics , optics , enzyme , chemistry
A bstract : Few risk factors for pancreatic cancer have emerged except for chronic pancreatitis. Recently, hereditary pancreatitis was estimated to carry a standardized incidence ratio of 53, a risk about 25 times higher than smoking. A review of the ongoing hereditary pancreatitis study of the Midwest Multi‐center Pancreatic Study Group suggests that the risk of pancreatic cancer is related to long‐standing pancreatitis rather than to the cationic trypsinogen mutations. No recommendations can be made on screening patients with hereditary pancreatitis for pancreatic cancer at this time. However, prospective data, serum, and pancreatic juice should be collected and banked on consenting patients at risk as part of prospective, multicenter trials so that evidence‐based recommendations for hereditary pancreatitis and other types of chronic pancreatitis can be made in the future.