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Phasic Accumbal Firing May Contribute to the Regulation of Drug Taking during Intravenous Cocaine Self‐administration Sessions
Author(s) -
PEOPLES LAURA L.,
UZWIAK ANTHONY J.,
GEE FRED,
FABBRICATORE ANTHONY T.,
MUCCINO KATHRYN J.,
MOHTA BINAIFER D.,
WEST M.O.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb09322.x
Subject(s) - state (computer science) , gee , library science , administration (probate law) , sociology , psychology , political science , law , computer science , algorithm , machine learning , generalized estimating equation
Recent studies have applied chronic extracellular recording techniques to the intravenous cocaine self-administration paradigm to investigate the neurophysiological mechanisms that contribute to drug taking (e.g., Refs. 1–4). Data of one study suggest that a large percentage of nucleus accumbens (NAcc) neurons exhibit a change in firing during limited-access (fixed-ratio 1) self-administration sessions that is both synchronized to the self-infusion behavior and has a time course comparable to the interval that elapses between successive self-infusions. A firing pattern with such a time course may be involved in the regulation of the self-infusion behavior (cf. Ref. 4). The focus of the present study was to further characterize neurons that exhibit this firing pattern.