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Changes in Nociceptive and Anxiolytic Responses following Herpes Virus‐mediated Preproenkephalin Overexpression in Rat Amygdala Are Naloxone‐reversible and Transient
Author(s) -
KANG WEN,
WILSON STEVEN P.,
WILSON MARLENE A.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb09316.x
Subject(s) - south carolina , columbia university , (+) naloxone , physiology , medicine , antagonist , sociology , media studies , political science , receptor , public administration
These results using herpes virus-mediated gene transfer to overexpress enkephalin in the amygdala support the role of amygdalar opioids in the anxiolytic actions of benzodiazepines and supraspinal nociception (see ref. 1). These studies also demonstrate the usefulness of recombinant herpes virus in evaluating the role of single gene products within specific brain sites in pharmacological responses and complex behaviors.