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Adaptation to Chronic Hypoxia Confers Tolerance to Subsequent Myocardial Ischemia by Increased Nitric Oxide Production
Author(s) -
BAKER JOHN E.,
HOLMAN PATRICIA,
KALYANARAMAN B.,
GRIFFITH OWEN W.,
PRITCHARD KIRKWOOD A.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb09239.x
Subject(s) - nitric oxide , nitric oxide synthase , hypoxia (environmental) , nitrite , ischemia , medicine , endocrinology , chemistry , oxygen , nitrate , organic chemistry
A bstract : Chronic exposure to hypoxia from birth increased the tolerance of the rabbit heart to subsequent ischemia compared with age‐matched normoxic controls. The nitric oxide donor GSNO increased recovery of post‐ischemic function in normoxic hearts to values not different from hypoxic controls, but had no effect on hypoxic hearts. The nitric oxide synthase inhibitors L‐NAME and L‐NMA abolished the cardioprotective effect of hypoxia. Message and catalytic activity for constitutive nitric oxide synthase as well as nitrite, nitrate, and cGMP levels were elevated in hypoxic hearts. Inducible nitric oxide synthase was not detected in normoxic or chronically hypoxic hearts. Increased tolerance to ischemia in rabbit hearts adapted to chronic hypoxia is associated with increased expression of constitutive nitric oxide synthase.