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Effect of Antioxidant Trace Elements on the Response of Cardiac Tissue to Oxidative Stress a
Author(s) -
BARANDIER CHRISTINE,
TANGUY STÉPHANE,
PUCHEU SYLVIE,
BOUCHER FRANCOIS,
LEIRIS JOËL
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb09232.x
Subject(s) - antioxidant , oxidative stress , chemistry , reperfusion injury , trace element , ischemia , pharmacology , biochemistry , medicine , organic chemistry
A bstract : It is now well established that several trace elements, because of their involvement in the catalytic activity and spatial conformation of antioxidant enzymes, may contribute to the prevention of oxidative stress such as occurs upon reperfusion of ischemic tissue. The aim of this paper is (1) to review the role of these trace elements (Cu, Mn, Se, and Zn) in antioxidant cellular defenses in the course of post‐ischemic reperfusion of cardiac tissue, (2) to provide experimental data suggesting that variations in trace element dietary intake may modulate the vulnerability of cardiac tissue to ischemia‐reperfusion, and (3) to discuss in more detail the effect of Mn ions, which seem to play a special protective role against reperfusion injury. Some results obtained from experiments in animal models of myocardial reperfusion have shown that the dietary intake of such trace elements can modulate cardiac activity of antioxidant enzymes and, consequently, the degree of reperfusion damage. In addition, experimental data on the protective effects of an acute treatment with Mn are presented. Finally, experimental evidence on the protective role of salen‐Mn complexes, which exhibit catalytic SOD‐ and CAT‐like activities against reperfusion injury, are described. These complexes should be of considerable interest in clinical conditions.