Premium
Mobile Gene Cassettes and Integrons in Evolution
Author(s) -
HALL RUTH M.,
COLLIS CHRISTINA M.,
KIM MIJURNG,
PARTRIDGE SALLY R.,
RECCHIA GAVIN D.,
STOKES H. W.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08866.x
Subject(s) - integron , integrases , integrase , recombination , genetics , gene , biology , mobile genetic elements , site specific recombination , computational biology , plasmid , recombinase
Integrons and the site‐specific recombination systems encoded by them provide a simple mechanism for the addition of new genes to bacterial chromosomes. Although there is substantial divergence among the four known integron‐encoded integrases, they all recognize the recombination sites, known as 59‐base elements, that are associated with genes that are packaged in gene cassettes. In contrast, the integron‐associated recombination sites, attI sites, are preferentially recognized by the cognate integrase.