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Preclinical and Early Human Studies of Calcium and Colon Cancer Prevention
Author(s) -
LIPKIN MARTIN
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08729.x
Subject(s) - colorectal cancer , medicine , vitamin d and neurology , cancer prevention , cancer , disease , calcium , primary prevention , oncology , incidence (geometry) , physiology , bioinformatics , biology , physics , optics
Colorectal cancer continues to be a major cause of tumor mortality in the United States and other countries; despite attempts to improve the screening of high‐risk populaitons, the incidence of this disease is still very high. Therefore, chemoprevention continues to be an important goal for the primary prevention of colorectal cancer. Among recent chemopreventive approaches, the administration of calcium and vitamin D continue to be evaluated in both preclinical and clinical studies. Many experimental findings described below have indicated associations between high calcium and vitamin D intake and decreased risk for colorectal cancer.