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Evaluation of Cisplatin Ototoxicity in a Rat Animal Model
Author(s) -
HATZOPOULOS S.,
DI STEFANO M.,
ALBERTIN A.,
MARTINI A.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08643.x
Subject(s) - ototoxicity , anesthesia , otoacoustic emission , medicine , animal model , audiology , cochlea , cisplatin , compound muscle action potential , electrophysiology , hearing loss , chemotherapy
The ototoxic effects of cisplatin were evaluated by otoacoustic emissions and evoked auditory responses. A transient otoacoustic emissions protocol indicated no significant ototoxic effects in rats treated intravenously with 7.5 mg/kg/week for 2‐weeks. A chronic 6‐week treatment (2.5 mg/kg/week) monitored by 2 F 1 ‐ F 2 distortion product emissions presented significant SNR alterations in a narrow range of frequencies (5.04–5.66 kHz). An acute treatment of 15 mg/kg, using slow 30‐min intraperitoneal infusion, presented the highest DP and ABR alterations. The SNR at the 2 F 1 ‐ F 2 frequencies 6.34, 7.13, and 7.56 kHz was found significantly decreased, and ABR latency measurements from 8‐kHz burst stimuli verified these alterations.