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A Radical Demise: Toxins and Trauma Share Common Pathways in Hair Cell Death
Author(s) -
KOPKE RICHARD,
ALLEN KEITH A.,
HENDERSON DONALD,
HOFFER MICHAEL,
FRENZ DOROTHY,
VAN DE WATER THOMAS
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08641.x
Subject(s) - cochlea , reactive oxygen species , hearing loss , acoustic trauma , medicine , hair cell , audiology , inner ear , neuroscience , biology , microbiology and biotechnology
The pathologic similarities noted after ototoxic and/or traumatic injury to the cochlea as well as the key features of the cochlea that make it susceptible to reactive oxygen species (ROS) damage are reviewed. Recent evidence linking ROS to cochlear damage associated with both ototoxins and/or trauma are presented. Mechanisms of generation of ROS in the cochlea and how these metabolites damage the cochlea and impair function are also reviewed. Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings.