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An Animal Model Based on the Sprague Dawley Rat for the Evaluation of Ototoxicity
Author(s) -
MARTINI A.,
HATZOPOULOS S.,
RUBINI R.,
DI STEFANO M.,
ALBERTIN A.,
GOVONI E.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08638.x
Subject(s) - ototoxicity , animal model , hyaluronic acid , pharmacology , electrophysiology , chemistry , medicine , anatomy , chemotherapy , cisplatin
Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague‐Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy‐propyl‐methyl‐cellulose) substances.