Premium
IGF‐I Promotes Peripheral Nervous System Myelination
Author(s) -
CHENG HSINLIN,
RUSSELL JAMES W.,
FELDMAN EVA L.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08575.x
Subject(s) - dorsal root ganglion , axon , neuroscience , peripheral nervous system , schwann cell , insulin like growth factor , biology , nervous system , peripheral , microbiology and biotechnology , growth factor , central nervous system , chemistry , spinal cord , medicine , receptor , biochemistry
Insulin‐like growth factor‐I (IGF‐I) promotes the proliferation and differentiation of Schwann cells (SC). We use SC/dorsal root ganglion neuron (DRG) cocultures to examine the effects of IGF‐I on the interaction between axons and SC. As SC extend processes toward the axon in the presence of IGF‐I, these processes attach to and ensheath axons. Continued IGF‐I exposure leads to enhanced P 0 expression and long‐term myelination. No myelination occurs in the absence of IGF‐I. These data imply that IGF‐I is critical not only for SC attachment and ensheathment of axons but also for long‐term myelination.