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New Multicomponent Capsules for Immunoisolation
Author(s) -
BARTKOWIAK ARTUR,
CANAPLE LAURENCE,
CEAUSOGLU ION,
NURDIN NATHALIE,
RENKEN ANDREAS,
RINDISBACHER LORENZ,
WANDREY CHRISTINE,
DESVERGNE BÉATRICE,
HUNKELER DAVID
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08499.x
Subject(s) - polyelectrolyte , materials science , rendering (computer graphics) , biomedical engineering , chemical engineering , nanotechnology , composite material , polymer , computer science , engineering , computer graphics (images)
A new generation of microcapsules based on the use of oligomers which participate in polyelectrolyte complexation reactions has been developed. These freeze‐thaw stable capsules have been applied as a bioartificial pancreas and have resulted in normoglycemia for periods of six months in concordant xenotransplantations. The new chemistry permits the control of permeability and mechanical properties over a wide range and can be adapted both to microcapsule and hollow fiber geometries rendering it a robust tool for encapsulation in general. Methods, and metrics, for the characterization of the mechanical properties and permeability of microcapsules are presented.