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Stem Cells, Pre‐Progenitor Cells and Lineage‐Committed Cells: Are Our Dogmas Correct?
Author(s) -
METCALF D.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08473.x
Subject(s) - haematopoiesis , progenitor cell , stem cell , lineage (genetic) , microbiology and biotechnology , biology , bioassay , cytokine , immunology , gene , genetics
A bstract : Recent developments warrant careful reexamination of several of the central dogmas of hematopoiesis. The bioassays previously used may have predetermined which subsets of hematopoietic stem cells are regarded as having long‐term repopulating activity and thus have produced misleading data. Lineage commitment in multipotential cells has been regarded as an immutable stochastic process but may be a process that can be modified by extrinsic signaling. Finally, loss of self‐renewal activity has been regarded as progressive and irreversible but this response to signaling can be blocked by cytokine‐inducible modulating proteins.