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Embryonic Beginnings of Definitive Hematopoietic Stem Cells
Author(s) -
DZIERZAK ELAINE
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08470.x
Subject(s) - haematopoiesis , stem cell , hemangioblast , embryonic stem cell , microbiology and biotechnology , biology , yolk sac , hematopoietic stem cell , adult stem cell , embryo , immunology , stem cell factor , genetics , gene
A bstract : The ability of the many cell types within the adult blood system to be constantly replenished and renewed from hematopoietic stem cells is an interesting problem in development and differentiation and has led to questions concerning how, when and where thses stem cells for the adult hematopoietic system are generated within the embryo. During embryonic development many mature hematopoietic cells appear before adult‐type hematopoietic stem cells thus the notion of a conventional hematopoietic hierarchy is challegned. Experiments probing the development of hematopoietic stem cells in the mouse embryo strongly suggest that at least two independent hematopoietic sites generate blood cells during development; the yolk sac, which produces the transient embryonic hematopoietic system, and the AGM (aorta‐gonad‐mesonephros) region, which initiates the long‐lived adult hematopoietic system.