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Absence of CD34 on Some Human SCID‐Repopulating Cells
Author(s) -
DICK JOHN E.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08466.x
Subject(s) - repopulation , haematopoiesis , nod , cd34 , stem cell , immunology , biology , microbiology and biotechnology , in vivo , severe combined immunodeficiency , cancer research , genetics
A bstract : The availability of in vivo repopulation assays had greatly aided the study of human hematopoietic stem cells. Here, I shall review recent data that has identified a novel class of human repopulating cells that do not express classical stem cell markers including CD34 but still retain the ability to repopulate nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice.