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Biology of IL‐8‐Induced Stem Cell Mobilization
Author(s) -
FIBBE WILLEM E.,
PRUIJT JOHANNES F.M.,
VELDERS GERJO A.,
OPDENAKKER GHISLAIN,
KOOYK GYVETTE VAN,
FIGDOR CARL G.,
WILLEMZE ROEL
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb08454.x
Subject(s) - mobilization , microbiology and biotechnology , stem cell , chemistry , biology , political science , law
A bstract : The CXC chemokine interleukin‐8 (IL‐8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the β2‐integrin leukocyte function‐associated antigen‐1 (LFA‐1). In monkeys, systemic injection of IL‐8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase‐B (MMP‐9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL‐8‐induced stem cell mobilization by the release of proteinases.