Premium
N ‐Acetylserotonin, Melatonin and Their Derivatives Improve Cognition and Protect against β‐Amyloid‐Induced Neurotoxicity
Author(s) -
BACHURIN S.,
OXENKRUG G.,
LERMONTOVA N.,
AFANASIEV A.,
BEZNOSKO B.,
VANKIN G.,
SHEVTZOVA E.,
MUKHINA T.,
SERKOVA T.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07990.x
Subject(s) - melatonin , neurotoxicity , neurotoxin , cholinergic , chemistry , pharmacology , medicine , toxicity , biochemistry
After a single injection of cholinergic neurotoxin ethylcholine aziridinium (AF64A, 3 nmol intracerebroventricularly (i.c.v.)), rats failed to perform the tasks in the active avoidance (learning and retention paradigms) and water maze tests. N ‐Acetylserotonin (NAS), melatonin and their newly synthesized derivatives, CA‐15 and CA‐18, (0.3‐3.0 mg/kg daily for 12–14 days) reversed the effect of AF64A in a dose‐dependent manner with CA‐18 being the most active. Melatonin and NAS caused sedation absent in CA‐18‐treated rats. The studied compounds (25–500 μM for 72 hr) protected against β‐amyloid peptide (βAP) fragment 25–35‐induced neurotoxicity in cerebellar granule cell culture. Our results suggest that neuroprotecting properties of these compounds might mediate their cognition‐enhancing effects. The results obtained warrant the further search for the novel types of safe neuroprotectors among the synthetic NAS/melatonin derivatives.