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Hyperoxia in Cell Culture: A Non‐apoptotic Programmed Cell Death
Author(s) -
KAZZAZ JEFFREY A.,
HOROWITZ STUART,
LI YUCHI,
MANTELL LIN L.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07930.x
Subject(s) - hyperoxia , programmed cell death , microbiology and biotechnology , apoptosis , signal transduction , mapk/erk pathway , biology , cell , chemistry , genetics , oxygen , organic chemistry
Here we discuss the morphological features and our current understanding of the pathways involved in non‐apoptotic cell death from O 2 toxicity. Preliminary data on hyperoxic signaling indicate that NF‐κB translocation (and presumptive activation) is not a result of the p42/p44 MAPK pathway, but a likely downstream consequence of activation of the JNK pathway. Our observations suggest the existence of multiple signal transduction pathways in hyperoxia‐induced cell death: one involved in the stress response which appears to be NF‐κB‐dependent and another in cell death.